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Little is known regarding the use of, and factors related with, interaction-oriented practices. In this study we investigate instructors’ use of interaction-oriented practices in online college courses. We begin by drawing on several strands of literature to offer a person-purpose interaction framework for categorizing interaction-oriented practices. The framework’s six sub-domains integrate for whom students are interacting (instructor, student, content) with the interaction’s pedagogical purpose (academic, social, managerial). Subsequently, we examine factors that predict instructors’ use of these six domains of practices, including instructors’ characteristics and their perceptions of online learning, using a sample of (n = 126) community college instructors teaching online courses. The results show that instructors using more interaction-oriented practices consistently have greater employment status and teaching load, greater self-efficacy for using learning management systems, and greater perceived benefits of online learning for students, with subtle distinctions found across sub-domains. The findings have several implications for future research examining pedagogical behavior, as well as the design of professional development activities aimed at enhancing the use of effective online instructional practices among college instructors.